Alkaloid Furokuinolin dan Asam Sinamat Ter-O-Geranilasi dari Kulit Batang Melicope hookeri T.G. HARTLEY
DOI:
https://doi.org/10.25026/jsk.v2i1.93Keywords:
Melicope hookeri, furokuinoline alkaloid, cinnamate acid, , anticancerAbstract
One furokuinoline alkaloid, evolitrine (1), and one cinnamate acid, trans 3-methyl-4-geranil caffeic acid (2) were isolated from the stem bark of Melicope hookeri. The structures of both compounds were determined based on spectroscopic data such as UV, IR, MS and NMR. Compounds 1–2 were evaluated for their anticancer activity against murin leukemia P-388 cells, showing their IC50 were 4,06 ± 0,15 and 4,86 ± 0,30 µg/ml, and two compounds showed moderate activity.
References
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Heyne, K., 1987. Tumbuhan Berguna Indonesia, Jilid II, Badan Penelitian dan Pengembangan Kehutanan, Departemen Kesehatan Republik Indonesia, Jakarta.
Kassim, N.K., Rahmani, M., Ismail, A., Sukari, M.A., Ee, G.C.L., Nasir, N.M., Awang, K., 2013. Antioxsidant activity-guided separation of coumarins and lignan from Melicope glabra (Rutaceae). Food Chem. 139: 87-92.
Li, S-G., Tian, H-Y,. Ye, W-C,. Jiang, R-W. 2011. Benzopyrans and furoquinoline alkaloids from Melicope ptelefolia. Biochem. Sys. Ecol.39: 64-67.
Ramli, I., Kamarulzaman, N.H., Shaari, K., Ee, G.C.L., 2004, p-O-Geranylcoumaric acid from Melicope lunu-ankeda, Nat. Prod. Res., 18(4): 289-294.
Simonsen, H.T., Adsersen, A,. Bremner, P,. Heinrich, M., Smitt, U.W., Jaroszewski, J.W. 2004. Antifungal constituents of Melicope borbonica. Phytoter. Res. 18: 542-545.
Saputri, R.D., Tjahjandarie, T.S., Tanjung, M. 2018. Alkaloid kuinolin dari Melicope denhamii dan uji aktivitas antikankernya. J,Sains dan Kesehatan. 9(1): 505-509.
Tanjung, M., Saputri, R.D., Tjahjandarie, T.S., 2017. 4-Methoxy-3-(3-methylbut-2-en-1-yl)-7-((3-methylbut-2-en-1-yl)oxy) quinolin-2(1H)-one from Melicope moluccana T.G. Hartley. Molbank. M939. 2: 1-5.
Tanjung, M., Rachmadiarti, F., Saputri, R.D., Tjahjandarie, T.S. 2018. Mesucalophylloidin, a new isoprenylated 4-phenylcoumarin from Mesua calophylloides (Ridl.) Kosterm.. Nat. Prod. Res. 32(9): 1062-1067.
Tanjung M, Mujahidin D, Hakim EH, Darmawan A, Syah Y.M. 2010. Geranylated flavonols from Macaranga rhizinoides. Nat Prod Commun. 5:1209-1211.
Tjahjandarie, T.S., Tanjung, M., 2015. Lead compound antimalaria dan antioksidan senyawa alkaloid, flavonoid, dan kumarin dari Limonia accidisima L.. Laporan Akhir Penelitian Unggulan Perguruan Tinggi, Universitas Airlangga. 1-45.
Tjahjandarie, T.S.; Saputri, R.D.; Tanjung, M. 2017. 5,9,11-Trihydroxy-2,2-dimethyl-3-(2-methylbut-3-en-2-yl)pyrano[2,3-a] xanthen-12(2H)-one from the stem bark of Calophyllum tetrapterum Miq. Molbank. M936. 1: 1-5.
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Published
2019-06-30
How to Cite
Saputri, R. D., Tjahjandarie, T. S., & Tanjung, M. (2019). Alkaloid Furokuinolin dan Asam Sinamat Ter-O-Geranilasi dari Kulit Batang Melicope hookeri T.G. HARTLEY. Jurnal Sains Dan Kesehatan, 2(1), 1–7. https://doi.org/10.25026/jsk.v2i1.93
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