Evaluasi Karakteristik Fisik dan Uji Permeasi Pada Formula Patch Aspirin Menggunakan Kombinasi Etilselulosa dengan Polivinilpirolidon

  • Arfiani Arifin Program Studi Farmasi, Fakultas MIPA, Universitas Islam Makassar
  • Sartini Sartini Fakultas Farmasi, Universitas Hasanuddin
  • Marianti Marianti Fakultas Farmasi, Universitas Hasanuddin
Keywords: aspirin, patch, etilselulosa, PVP K-30

Abstract

Penelitian ini bertujuan mengetahui kombinasi perbandingan polimer etilselulosa dan PVP K-30 yang menghasilkan karakteristik fisik baik dan pengaruhnya terhadap permeasi kulit pada hewan coba. Pengujian yang dilakukan meliputi pengujian fisik yaitu uji organoleptik, kadar air, ketebalan, dan keseragaman bobot, serta uji permeasi kulit pada hewan coba menggunakan membran kulit tikus dan kelinci. Perbandingan formulasi etilselulosa dan PVP K-30  yang digunakan adalah 7:3 (F1), 8:2 (F2) dan 9:1 (F3). Patch dibuat dengan menggunakan metode solvent casting atau dikenal metode cetak tuang. Hasil penelitian menunjukkan bahwa kombinasi perbandingan polimer etilselulosa dan PVP K-30 yang menghasilkan karakteristik fisik baik adalah F2 (8:2) dan F3 (9:1). Berdasarkan hasil pengujian terhadap uji permeasi menggunakan membran kulit tikus dan kelinci dapat disimpulkan bahwa formula optimum yaitu F3 (9:1) dengan nilai permeasi tertinggi pada tikus 46,09% dan kelinci 66,30 %.

 

 

 

References

Huang Y, Li M, Li JY, Li M, Xia YP, Mao L, et al. The Efficacy and Adverse Reaction of Bleeding of Clopidogrel plus Aspirin as Compared to Aspirin Alone after Stroke or TIA: A Systematic Review. PLoS One. 2013;8(6).

Presley B. Penatalaksanaan Farmakologi Stroke Iskemik Akut. Bul Rasional [Internet]. 2013;12(1):6–8. Available from: http://repository.ubaya.ac.id/21378/1/Rasional Vol 12 No 1.pdf

Awtry EH, Loscalzo J. Aspirin. Circulation. 2000;101:1206–18.

Lauer MS. Aspirin For Primary Prevention of Coronary Events. N Engl J Med [Internet]. 2002;346(19):1468–70. Available from: http://jasoncartermd.com/resources/pdf/Aspirin for Primary Prevention of Coronary Events.pdf

Patrono C, Rocca B. Aspirin: Promise and resistance in the new millennium. Arterioscler Thromb Vasc Biol. 2008;28(3):25–33.

Kannan S, Manivannan R, Balasubramaniam A, Kumar NS. Formulation and Evaluation of Aspirin Delayed Release Tablet. Pharm Glob Int J Compr Pharm. 2010;1(4):1–3.

McEvoy GK, editor. AHFS Drug Information. Bethesda USA: American Society of Healt-System Pharmacist; 2002.

Amjad M, Ehtheshamuddin M, Chand S, Hanifa, Sabreesh M, Asia R, et al. Formulation and Evaluation of Transdermal Patches of Atenolol. Adv Res Pharm Biol. 2011;1(2):109–19.

Ammar H, Ghorab M, El-Nahhas S, Kamel R. Evaluation of chemical penetration enhancers for transdermal delivery of aspirin. Asian J Pharm Sci [Internet]. 2007;2(3):96–105. Available from: http://www.asianjps.com:8080/Jweb_ajps/CN/article/downloadArticleFile.do?attachType=PDF&id=120

Shamsher A, Charoo N, Kohli K, Pillai K, Rahman Z. Effect of Transdermally Delivered Aspirin on Blood Coagulation Parameters. Am J Biomed Sci [Internet]. 2010;2(2):129–41. Available from: http://www.nwpii.com/ajbms/papers/AJBMS_2010_2_04.pdf

Banerjee A, Harun al Rashid M, Chakraverty R, Dey S, Basak D, Biswas C. Preparation and evaluation of aspirin transdermal patch using HPMC. Int J Pharm Sci Rev Res. 2012;15(1):45–6.

Kandavilli S, Nair V, Panchagnula R. Polymers in Transdermal. Pharm Technol. 2002;(May):62–80.

Ansel HC. Pengantar Bentuk Sediaan Farmasi Edisi Keempat. Jakarta: UI Press; 1989.

Hendradi E, Isnaeni, Pujianti E, Fridayanti A. Optimasi Efektivitas Diklofenak. 2010;

Mukherjee B, Kanupriya, Mahapatra S, Das S, Patra B. Sorbitan monolaurate 20 as a potential skin permeation enhancer in transdermal patches. J Appl Res. 2005;5(1):96–108.

Ubaidulla U, Reddy MVS, Ruckmani K, Ahmad FJ, Khar RK. Transdermal Therapeutic System of Carvedilol: Effect of Hydrophilic and Hydrophobic Matrix on In Vitro and In Vivo Characteristics. AAPS PharmSciTech. 2007;8(1):2–8.

Shirsand SB, Ladhane GM, Prathap S, Prakash P. Design and evaluation of matrix type of transdermal patches of methotrexate. RGUHS J Pharm Sci. 2012;2(4):58–65.

Madhulatha, Naga R. Formulation and evaluation of ibuprofen transdermal patches. Int J Res pharmactical bio Med Sci. 2013;4(1):351–62.

Kumar R, Philip A. Modified Transdermal Technologies: Breaking the Barriers of Drug Permeation via the Skin. Trop J Pharm Res [Internet]. 2007;6(1):633–44. Available from: http://www.ajol.info/index.php/tjpr/article/view/14641

Rowe R, Sheskey P, Quinn M. Handbook of Pharmaceutical Excipients. Handb Pharm excipients, Sixth Ed. 2009;549–53.

Garala KC, Shinde AJ, Shah PH. Formulation and in-vitro characterization of monolithic matrix transdermal systems using HPMC/Eudragit S 100 polymer blends. Int J Pharm Pharm Sci. 2009;1(SUPPL. 1):108–20.

Published
2019-06-30
How to Cite
Arifin, A., Sartini, S., & Marianti, M. (2019). Evaluasi Karakteristik Fisik dan Uji Permeasi Pada Formula Patch Aspirin Menggunakan Kombinasi Etilselulosa dengan Polivinilpirolidon. Jurnal Sains Dan Kesehatan, 2(1), 40-49. https://doi.org/10.25026/jsk.v2i1.103