Skrining Fitokimia dan Profil Kromatografi Lapis Tipis (KLT) Tumbuhan Antimalaria Asal Indonesia

Phytochemical Screening and Thin Layer Chromatography Profile of Indonesia Plants

  • Muhammad Arifuddin Faculty of Pharmacy, Mulawarman University
  • Mahfuzun Bone
Keywords: Phytochemical, Metabolite, Secondary, Antimalarial

Abstract

Phytochemical screening tests have been carried out to detect secondary metabolites in several plants, namely Brotowali stem (Tinospora crispa), Jambu Biji leaves (Psidium guajava), Manggis rind (Garcinia mangostana), Pare fruit (Momordica charantia), Pepaya leaves (Carica papaya), Pulai sari stem bark (Alstonia scholaris), Sirsak leaves (Annona muricata). The test results obtained the state that each sample of the plant contains secondary metabolites which have the potential as antimalarial compounds.

References

1. Depkes RI. 2016. InfoDATIN Malaria Pusat Data dan Informasi Kementrian Kesehatan RI. Jakarta.
2. Leaman, D., Arnason, J., Yusuf, R., Sangat-Roemantyo, H., Soedjito, H., Angerhofer, C. and Pezzuto, J. 1995. Malaria remedies of the Kenyah of the Apo Kayan, East Kalimantan, Indonesian Borneo: A quantitative assessment of local consensus as an indicator of biological efficacy. Journal of Ethnopharmacology, 49(1), pp.1-16.
3. Due R., Symaswisna Dan Marlina, R. (2013). Etnobotani Tumbuhan Obat Suku Dayak Pesaguan Dan Implementasinya Dalam Pembuatan Flash Card Biodiversitas. Artikel Penelitian. Program Studi Pendidikan Biologi Fkip Untan Pontianak.
4. Sari, R.Y., Wardenaar, E. dan Muflihati. 2014. Etnobotani Tumbuhan Obat Di Dusun Serambai Kecamatan Kembayan Kabupaten Sanggau Kalimantan Barat. Jurnal Hutan Lestari, Vol 2, No 3.
5. Abdillah, S., Tambunan, R., Sinaga, Y. and Farida, Y. 2014. Ethno-botanical survey of plants used in the traditional treatment of malaria in Sei Kepayang, Asahan of North Sumatera. Asian Pacific Journal of Tropical Medicine, 7, pp.S104-S107.
6. Krettli, A., Andrade-Neto, V., Brandão, M. and Ferrari, W. 2001. The search for new antimalarial drugs from plants used to treat fever and malaria or plants ramdomly selected: a review. Memórias do Instituto Oswaldo Cruz, 96(8), pp.1033-1042.
7. Depkes RI. 1995. Farmakope Indonesia. Edisi IV. Jakarta: Departemen Kesehatan Republik Indonesia. P.7, 1036-1043.
8. Farnsworth, N.R. 1996. Biological and Phytochemical screening of Plants. Journal of Pharmaceutical Science. Chicago. Rheins Chemical Company. Vol. 55. Number 3, Pages 264,
9. Ciulei, J. 1984. Metodology for Analysis of Vegetables and Drugs. Bucharest: Faculty of Pharmacy. Pp. 11-26.
10. Depkes RI. 1989. Materia Medika Indonesia, Jilid V. Jakarta: Departemen Kesehatan Republik Indonesia. Halaman: 549-553.
11. Harborne, J.B. 1987. Metode Fitokimia: Penuntun Cara Modern Menganalisis Tumbuhan, Terbitan Kedua. Bandung : Penerbit ITB. Hal. 239.
12. Sebisubi FM, Tan GT. 2011. Natural products with antimalarial activity, in Phytochemistry and Pharmacognosy section, Chemical Sciences, Engineering and Technology Resources. Encyclopedia of Life Support Systems (EOLSS), Developed under the Auspices of the UNESCO. EOLSS Publishers. Oxford, UK. (http://www.eolss.net).
13. Somsak, V., Polwiang, N., Chachiyo, S. 2016. In Vivo Antimalarial Activity of Annona muricata Leaf Extract in Mice Infected with Plasmodium berghei. Journal of Pathogens. Volume 2016, Article ID 3264070, 5 pages. doi.org/10.1155/2016/3264070
14. Ahmad, W., Jantan, I., & Bukhari, S. N. 2016. Tinospora crispa (L.) Hook. f. & Thomson: A Review of Its Ethnobotanical, Phytochemical, and Pharmacological Aspects. Frontiers in Pharmacology, 7. doi:10.3389/fphar.2016.00059
15. Lee, W. C., Mahmud, R., Noordin, R., Piaru, S. P., Perumal, S., & Ismail, S. 2012. Alkaloids content, cytotoxicity and anti-Toxoplasma gondii activity of Psidium guajava L. and Tinospora crispa. Bangladesh Journal of Pharmacology, 7(4). doi:10.3329/bjp.v7i4.12499
16. Christina, C., Kumar, S.P., Beula, J.M., Lekha, N.C., Jeyaraj, N., Ravikumar, S. 2015. In vitro antiplasmodial activity of Kani herb Alstonia scholaris against Plasmodium falciparum. Innovative Journal of Medical and Health Science, 5(4). doi:10.15520/ijmhs.2015.vol5.iss4.81.166-169
17. Dey, A,. 2011. Alstonia scholaris R.Br. (Apocynaceae): Phytochemistry and pharmacology: A concise review. Journal of Applied Pharmaceutical Science 01 (06); 2011: 51-57
18. Gandhi, M., & Vinayak, V. K. 1990. Preliminary evaluation of extracts of Alstonia scholaris bark for in vivo antimalarial activity in mice. Journal of Ethnopharmacology, 29(1), 51-57. doi:10.1016/0378-8741(90)90097-d
19. Wright, C. W., Allen, D., Phillipson, J., Kirby, G. C., Warhurst, D. C., Massiot, G., & Men-Olivier, L. L. 1993. Alstonia species: Are they effective in malaria treatment? Journal of Ethnopharmacology, 40(1), 41-45. doi:10.1016/0378-8741(93)90087-l
20. Ngbolua, J. K. 2018. A review on the Phytochemistry and Pharmacology of Psidium guajava L. (Myrtaceae) and Future direction. Discovery Phytomedicine, 5(2). doi:10.15562/phytomedicine.2018.58
21. Gutiérrez, R. M., Mitchell, S., & Solis, R. V. 2008. Psidium guajava: A review of its traditional uses, phytochemistry and pharmacology. Journal of Ethnopharmacology, 117(1), 1-27. doi:10.1016/j.jep.2008.01.025
22. Yogiraj, V., Goyal, P.K., Chauhan, C.S., Goyal, A., Vyas, B. 2014. Carica papaya Linn: An Overview. International Journal of Herbal Medicine, 2014; 2 (5): 01-08
23. Moghadamtousi, S., Fadaeinasab, M., Nikzad, S., Mohan, G., Ali, H., & Kadir, H. 2015. Annona muricata (Annonaceae): A Review of Its Traditional Uses, Isolated Acetogenins and Biological Activities. International Journal of Molecular Sciences, 16(7), 15625-15658. doi:10.3390/ijms160715625
24. Singh, R.M., Cummings, E., Patel, M., Jeeboo, K., Singh, J. 2017. Anti-cancer properties of bioactive compounds isolated from Momordica charantia: A mini review. Advancement in Medicinal Plant Research Vol. 4(3), pp. 83-93.
25. Desai, S., Tatke, P. 2017. Charantin: An important lead compound from Momordica charantia for the treatment of diabetes. Journal of Pharmacognosy and Phytochemistry 2015; 3(6): 163-166
26. Singh, J., Cumming, E., Manoharan, G., Kalasz, H., & Adeghate, E. 2011. Medicinal Chemistry of the Anti-Diabetic Effects of Momordica Charantia: Active Constituents and Modes of Actions. The Open Medicinal Chemistry Journal, 5(Suppl 2), 70-77. doi:10.2174/1874104501105010070
27. Liu, H., Wang, G., Zhang, M., & Ling, B. 2015. The cytotoxicology of momordicins I and II on Spodoptera litura cultured cell line SL-1. Pesticide Biochemistry and Physiology, 122, 110-118. doi:10.1016/j.pestbp.2014.12.007
28. Katiyar, D., Vijender Singh V., Ali, M. 2017. Phytochemical and Pharmacological Profile of Momordica charantia : A Review Biochemistry and Therapeutic Uses of Medicinal Plants. Discovery Publishing House Pvt. Ltd. New Delhi (India)
29. Shehab Ali Yousif, S.A. In Vitro Screening of Antiplasmodium Activity of Momordica Charantia. 2014. Jour. of Nat. Resour. & EnviroN. STU. , 2. 3, 29-33, (10) 2014
30. Ueno HM., Doyama JT., Padovani CR., Salata E. 1996. Effect of Momordica charantia L. in mice infected with Plasmodium berghei. Rev Soc Bras Med Trop. 1996 Sep-Oct;29(5):455-60.
31. Ibrahim, S. R., Abdallah, H. M., El-Halawany, A. M., Nafady, A. M., & Mohamed, G. A. 2018. Mangostanaxanthone VIII, a new xanthone from Garcinia mangostana and its cytotoxic activity. Natural Product Research, 1-8. doi:10.1080/14786419.2018.1446012
32. Ibrahim, S. R., Mohamed, G. A., Elfaky, M. A., Zayed, M. F., El-Kholy, A. A., Abdelmageed, O. H., & Ross, S. A. 2018. Mangostanaxanthone VII, a new cytotoxic xanthone from Garcinia mangostana. Zeitschrift Für Naturforschung C, 73(5-6), 185-189. doi:10.1515/znc-2017-0122
33. Ibrahim, S. R., Mohamed, G. A., Elfaky, M. A., Haidari, R. A., Zayed, M. F., El-Kholy, A. A., & Khedr, A. I. 2018. Garcixanthone A, a new cytotoxic xanthone from the pericarps of Garcinia mangostana. Journal of Asian Natural Products Research, 1-7. doi:10.1080/10286020.2017.1423058
34. Wang, J. J., Sanderson, B. J., & Zhang, W. 2011. Cytotoxic effect of xanthones from pericarp of the tropical fruit mangosteen (Garcinia mangostana Linn.) on human melanoma cells. Food and Chemical Toxicology, 49(9), 2385-2391. doi:10.1016/j.fct.2011.06.051
Published
2020-06-30
How to Cite
Arifuddin, M., & Bone, M. (2020). Skrining Fitokimia dan Profil Kromatografi Lapis Tipis (KLT) Tumbuhan Antimalaria Asal Indonesia. Jurnal Sains Dan Kesehatan, 2(3), 174-181. https://doi.org/10.25026/jsk.v2i3.113