Flavonoid dalam Penyembuhan Luka Bakar pada Kulit

Flavonoids in Healing Burns on the Skin


  • Gede Reynaldi Wahyu Sanjaya Program Studi Sarjana Kedokteran Fakultas Kedokteran Universitas Udayana, Indonesia https://orcid.org/0009-0005-3265-3158
  • Ni Made Linawati Departemen Histologi Fakultas Kedokteran Universitas Udayana, Indonesia https://orcid.org/0000-0002-6251-9399
  • I Gusti Kamasan Nyoman Arijana Departemen Histologi Fakultas Kedokteran Universitas Udayana, Indonesia
  • Ida Ayu Ika Wahyuniari Departemen Histologi Fakultas Kedokteran Universitas Udayana, Indonesia
  • I Gusti Nyoman Sri Wiryawan Departemen Histologi Fakultas Kedokteran Universitas Udayana, Indonesia




luka bakar, struktur histologi kulit, flavonoid, penyembuhan luka bakar


Burns can be caused by heat or other acute trauma, currently the number of cases is still high in Indonesia and the world. The advances of burns treatment are made through research on possible natural ingredients. Flavonoids are polyphenolic compounds that are most commonly found in plants and as well as possible in burn healing. The aims of this literature review are decribed burns, histological structure of skin, and the effectiveness of flavoinoids in burns healing. The method used in this literature review is by searching data through the Science Direct, PubMed, and Google chrome databases. The search results of 19 appropriate journals, it was found that the flavonoid compounds can heal burns through their ability to inhibit prostanoid biosynthesis, inhibition of phosphodiesterase, and various other important mechanisms.


Smolle C, Cambiaso-Daniel J, Forbes AA, Wurzer P, Hundeshagen G, Branski LK, et al. Recent trends in burn epidemiology worldwide: A systematic review. Burns. 2017;43(2):249–57.

Wardhana A, Basuki A, Prameswara ADH, Rizkita DN, Andarie AA, Canintika AF. The epidemiology of burns in Indonesia’s national referral burn center from 2013 to 2015. Burn Open [Internet]. 2017;1(2):67–73. Availablefrom: https://doi.org/10.1016/j.burnso.2017. 08.002

Maleki SJ, Crespo JF, Cabanillas B. Anti-inflammatory effects of flavonoids. Food Chem. 2019;299(July).

Noorbakhsh SI, Bonar EM, Polinski R, Amin MS. Educational Case: Burn Injury-Pathophysiology, Classification, and Treatment. Acad Pathol. 2021;8.

Hettiaratchy S, Dziewulski P. Pathophysiology of burns. Point Vet. 2018;49(384):32–5.

Jeschke MG, van Baar ME, Choudhry MA, Chung KK, Gibran NS, Logsetty S. Burn injury. Nat Rev Dis Prim [Internet]. 2020;6(1). Available from: http://dx.doi.org/10.1038/s41572-020-0145-5

Evers LH, Bhavsar D, Mailänder P. The biology of burn injury. Exp Dermatol. 2010;19(9):777–83.

Nielson CB, Duethman NC, Howard JM, Moncure M, Wood JG. Burns: Pathophysiology of Systemic Complications and Current Management. J Burn Care Res. 2017;38(1):e469–81.

Bergfelt DR. Anatomy and Physiology of the Mare. Equine Breed Manag Artif Insemin. 2009;113–31.

Arda O, Göksügür N, Tüzün Y. Basic histological structure and functions of facial skin. Clin Dermatol. 2014;32(1):3–13.

Cichorek M, Wachulska M, Stasiewicz A, Tymi?ska A. Skin melanocytes: Biology and development. Postep Dermatologii i Alergol. 2013;30(1):30–41.

Jaitley S, Saraswathi TR. Pathophysiology of Langerhans cells. J Oral Maxillofac Pathol. 2012;16(2):239–44.

Hindun S, Rusdiana T, Abdasah M, Hindritiani R. POTENSI LIMBAH KULIT JERUK NIPIS (Citrus auronfolia) SEBAGAI INHIBITOR TIROSINASE. Indones J Pharm Sci Technol. 2017;4(2):64.

Alassadi IJB, Abd-alla ZS. Isolation , identification and antibacterial aactivity of flavonoid compound 2008;30:357–62.

Liu RH. Dietary bioactive compounds and their health implications. J Food Sci. 2013 Jun;78(SUPPL.1).

Redha A. Flavonoid: Struktur, Sifat Antioksidatif dan Peranannya Dalam Sistem Biologis. J Berlin. 2010;9(2):196–202.

Arifin B, Ibrahim S. Struktur, Bioaktivitas Dan Antioksidan Flavonoid. J Zarah. 2018;6(1):21-9.

Rathee P, Chaudhary H, Rathee S, Rathee D, Kumar V, Kohli K. Mechanism of action of flavonoids as anti-inflammatory agents: A review. Inflamm Allergy-Drug Targets. 2009;8(3):229–35.

Ginwala R, Bhavsar R, Chigbu DGI, Jain P, Khan ZK. Potential role of flavonoids in treating chronic inflammatory diseases with a special focus on the anti-inflammatory activity of apigenin. Antioxidants. 2019;8(2):1–28.




How to Cite

Sanjaya, G. R. W., Linawati, N. M., Arijana, I. G. K. N., Wahyuniari, I. A. I., & Wiryawan, I. G. N. S. (2023). Flavonoid dalam Penyembuhan Luka Bakar pada Kulit: Flavonoids in Healing Burns on the Skin. Jurnal Sains Dan Kesehatan, 5(2), 243–249. https://doi.org/10.25026/jsk.v5i2.1247

Most read articles by the same author(s)