Formulasi dan Evaluasi Serum Gigi Ekstrak Etanol Siwak (Salvadora persica L.)
Formulation and Evaluation of Dental Serum from Siwak Ethanolic Extract (Salvadora persica L.)
DOI:
https://doi.org/10.25026/jsk.v5i2.1724Keywords:
Dental Serum, Siwak, Streptococcus mutansAbstract
Dental health is a common problem in society. Traditionally, siwak is used to prevent bleeding gums and has antimicrobial effects. In this study, a tooth serum was made from ethanol extract of siwak and its preparations were evaluated and its antibacterial effect was tested. The method used in this research was experimental and three formulations were made with different concentrations of ethanol extract of siwak, formulation 1 (21%), formulation 2 (42%), and formulation 3 (63%). The results of the preparation evaluation showed that the three formulations were not significantly different compared to the control based on organoleptic test, viscosity, pH, dispersion, and stability test. The antimicrobial effect test showed that the three formulations were able to inhibit streptococcus mutans. After the research, the conclusion that can be taken is that the three formulations of the tooth serum ethanol extract of siwak are pharmaceutically stable and formulation 3 showed the best antibacterial effect.
References
Kemenkes RI, Riset Kesehatan Dasar. Jakarta, 2013.
Kemenkes RI, Hasil Riset Kesehatan Dasar Tahun 2018. Jakarta, 2018.
N. aisyiyah listyasari and O. Santoso, “Inhibition of dental plaque formation by toothpaste containing propolis Listyasari and Santoso: Inhibition of dental plaque formation by toothpaste containing propolis introduction,” Dent. J., vol. 45, no. 4, pp. 208–211, 2012.
S. Amal, Riza Amalia, Nurul Marfu’ah, “Aktivitas Antibakteri Kayu Siwak (Salvadora persica) Fraksi Eter Terhadap Bakteri Staphylococcus aureus Secara In Vitro,” Pharm. J. Islam. Pharm., vol. 2, no. 1, p. 16, 2018.
M. Khatak, S. Khatak, A. Siddqui, N. Vasudeva, A. Aggarwal, and P. Aggarwal, “Salvadora persica,” Pharmacogn. Rev., vol. 4, no. 8, pp. 209–214, 2010.
M. Abhary and A.-A. Al-Hazmi, “ Antibacterial activity of Miswak ( Salvadora persica L.) extracts on oral hygiene ,” J. Taibah Univ. Sci., vol. 10, no. 4, pp. 513–520, 2016.
F. Nurainy, S. Rizal, and Yudiantoro, “Terhadap Aktivitas Antibakteri Dengan Metode Difusi,” J. Teknol. Ind. dan Has. Pertan., vol. 13, no. 2, pp. 117–125, 2008.
S. Sasidharan, P. Joseph, and Junise, “Formulation and evaluation of fairness serum using polyherbal extracts,” Int. J. Pharm., vol. 4, no. 3, pp. 105–112, 2014.
A. Febriani, I. Maruya, and F. Sulistyaningsih, “Formulasi dan Uji Iritasi Sediaan Gel Kombinasi Ekstrak Etanol Rimpang Kencur (Kaempferia galanga L.) dan Ekstrak Etanol Herba Pegagan (Centella asiatica (L.) Urban) Formulation and Irritation Test of Gel Combination of Galangal Rhizome (Kaempferia galang,” Ejournal.Istn.Ac.Id, vol. 13, no. 1, pp. 45–54, 2020.
W. W. Davis and T. R. Stout, “Disc plate method of microbiological antibiotic assay. I. Factors influencing variability and error.,” Appl. Microbiol., vol. 22, no. 4, pp. 659–665, 1971.
P. J. Sinko, Farmasi Fisika dan Ilmu Farmaseutika edisi 5. Diterjemahkan oleh Tim Alih Bahasa Sekolah Farmasi ITB. Jakarta: EGC, 2011.
N. A. Sayuti, “Formulasi dan Uji Stabilitas Fisik Sediaan Gel Ekstrak Daun Ketepeng Cina (Cassia alata L.),” J. Kefarmasian Indones., vol. 5, no. 2, pp. 74–82, 2015.
A. Martin and J. Swarbrick, Farmasi Fisika II. Jakarta: UI Press, 2008.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Jurnal Sains dan Kesehatan
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
