Isolasi, Karakterisasi, dan Uji Aktivitas Antioksidan Senyawa Turunan Kuersetin dari Kulit Batang Melicope quercifolia
Keywords:
Melicope quercifolia, pachypodol, ayanin, antioxidantAbstract
Two quercetin derivatives, pachypodol (1) and ayanin (2) were isolated from the stem bark of Melicope quercifolia (B.S. William) Ridl. Their structures were determined based on spectroscopic data such as UV, IR, MS and NMR. Compounds 1–2 were evaluated for their antioxidant against DPPH radical showing their IC50 were 254 ± 10 and 38.55 ± 0.02 µg/mL, respectively.
References
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[2] Kasim, N.K., Rahmani, M., Ismail, A., Sukari, M.A., Ee, G.C.L., Nasir, N.M., Awang, K., (2013). Antioxidant activity-guided separation of coumarins and lignan from Melicope glabra (Rutaceae). Food Chem. 139, 87-92.
[3] Saputri, R.D., Tanjung, M., Tjahjandarie, T.S., (2018a). Cytotoxic activity of quinolinone alkaloids and acylphloroglucinol from the leaves of Melicope denhamii. J. of Physics: Conference Series.1095(1), 012031.
[4] Tjahjandarie, Saputri, R.D., Wahjoedi, R.A., Tanjung, M., (2018). Melimoluccanin, a new isoprenylated quinolone alkaloid from the leaves of Melicope moluccana TG Hartley. J. of Physics: Conference Series.1095(1), 012042.
[5] Saputri, R.D., Tjahjandarie, T.S., Tanjung, M., (2018b). Meliglabrin, a new flavonol derivative from the leaves of Melicope glabra (Blume) TG Hartley. Nat. Prod. Sci.24(3), 155-158.
[6] Simonsen, H,T., Adersen, A., Bremmer, P., Heinrich, M., Smitt, U.W., Jaroszewski, J,W., (2004). Antifungal constituents of Melicope borbonica, Phytother. Res. 18, 542-545.
[7] Marliana, E., Tjahjandarie, T.S., Tanjung, M., (2016). Aktivitas antioksidan senyawa flavonoid dari Macaranga pearsonii Merr. J. Kimia Mulawarman. 13(2), 97-100.
[8] Khasanah, S.N.N.,Imaniah, N., Saputri, R.D., Tjahjandarie, T.S., Tanjung, M., (2018), Kumarin terisoprenilasi dan alkaloid indol dari kulit batang Zanthoxylum ovalifolium Tutcher. J. Kimia Mulawarman. 15(2), 76-81.
[9] Tjahjandarie, T.S., Saputri, R.D., Tanjung, M., (2016). Oxygeranylated coumarins from the root of Limonia accidisima L. and their DPPH radical scavenging activity. Der Pharmacia Lettre. 8, 33-36.
[10] Tanjung, M., Saputri, R.D., Tjahjandarie, T.S., (2016). Antimalarial and antioxidant of isoprenylated coumarins from the stem bark of Mesua borneensis L. J Biol. Active Prod from Nature. 6, 95-100.
[11] Tanjung M, Mujahidin D, Hakim EH, Darmawan A, Syah Y.M. (2010). Geranylated flavonols from Macaranga rhizinoides. Nat Prod Commun. 5,1209-1211.
[12] Ali, H.A., Chowdhury, A.K.A., Rahman, A.K.M., Borkowski, T., Nahar, L., Sarker, S.D., (2008). Pachypodol, a flavonol from the leaves of Calycapteris floribunda, inhibits the growth of colon cancer cell line in vitro, Phytother. Res.22, 1684–1687.
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Published
2020-12-31
How to Cite
Rahman, A., Mahardika, I., Saputri, R. D., Tjahjandarie, T. S., & Tanjung, M. (2020). Isolasi, Karakterisasi, dan Uji Aktivitas Antioksidan Senyawa Turunan Kuersetin dari Kulit Batang Melicope quercifolia. Jurnal Sains Dan Kesehatan, 2(4), 413–417. Retrieved from https://jsk.farmasi.unmul.ac.id/index.php/jsk/article/view/202
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