Aktivitas Anti Candida albicans ATCC 14053 Sediaan Pasta Gigi Gel Ekstrak Daun Jengkol (Archidendron pauciflorum) dengan Kombinasi Na-CMC dan Karbomer

Activity of Anti-Candida albicans ATCC 14053 Toothpaste Gel Leaf Extract Jengkol (Archidendron pauciflorum) with Combination of Na-CMC and Carbomer

  • Aria Agustina Achsia STIKes Karya Putra Bangsa Tulungagung
  • Ary Kristijono Prodi S1 Farmasi, STIKes Karya Putra Bangsa, Tulungagung
  • Dara Pranidya Tilarso Prodi S1 Farmasi, STIKes Karya Putra Bangsa, Tulungagung
Keywords: Jengkol Leaves, Antifungal, Gel toothpaste, Candida albicans

Abstract

Jengkol leaf extract can inhibit the growth of the fungus Candida albicans because it contains flavonoids, saponins, and tannins. Candida albicans species are most commonly found in the oral cavity that can cause various diseases in humans as canker sores and skin lesions. The purpose of this study was to formulate jengkol leaf extract into gel toothpaste preparations by distinguishing variations in the concentration of carbomer as a gelling agent. The research method used is experimental. Jengkol leaf samples extracted using the maceration method with 70% ethanol. The concentration of active substance used in each formula was 7.5% based on the preliminary test results and the carbomer concentration used was 0.5% in formula I, 1% in formula II, 1.5% in formula III, and 2% in formula IV. The physical stability test consists of organoleptic, homogeneity, spreadability, viscosity, pH, and high foam for 28 days of storage. Antifungal activity test using the disc diffusion method. Statistic analysis performed using the Shapiro-Wilk, Levene Statistics, and One Way Anova methods. During 28 days of keeping all formula homogeneous stable. The viscosity increased in each formulation due to differences in the concentration of carbomer used, the higher of carbomer the more viscous of the preparation, the pH, foam height of the formulation was stable and met the standard. The particles are evenly distributed so that the formulation colors and odors have stable. The result of the antifungal activity test of toothpaste gel extract of 7,5% jengkol leaf has inhibition of 11 mm. The increase in carbomer concentration showed a significant difference in each formula based on the One Way Anova statistical analysis (p <0.05) and the addition of carbomers to the formula showed stable viscosity and high foam. The most stable formula is the formula I with a carbomer concentration of 0.5%.

References

[1] Badan Standarisasi Nasional. SNI 12-3524-1995. Pasta Gigi. Jakarta: 1-16.

[2] Bakar, R.; Ahmad, I.; Sulaiman, S. 2012. Effect of Pithecellobium jiringa as antimicrobial agent. Bangladesh J Pharmacol; 7: 131-34.

[3] Bunawan, H.; Dusik, L.; Bunawan, S.; Amin, N. 2013. Botany, Traditional Use, Phytochemistry and Pharmacology of Archidendron jiringa: A review. Global Journal of Pharmacology 7 (4): 474-478, 2013.

[4] Butler. 2000. Poucher’s Perfume, Cosmetics, and Soap. 10th Edition. London: Kluwer Academic Publisher.

[5] Departemen Kesehatan RI. 2000. Parameter Standar Umum Ekstrak Tumbuhan Obat. Jakarta: Departemen Kesehatan Republik Indonesia-Direktorat Jenderal Pengawasan Obat dan Makanan-Direktorat Pengawasan Obat Tradisional.

[6] Harborne, J.B. 2006. Metode Fitokimia Penuntun Cara Modern Menganalisis Tumbuhan, Edisi ke-2. Bandung : ITB.

[7] Jariyah dan Oktaviani. 2016. The Activity Test Of Ethanol Extract Jengkol Skin (Pithecellobium Jiringa) To Inhibit Of Fungus Growth Candida Albicans. PROSIDING Vol 1-Sep 2016. ISSN: 2541-3023.

[8] Komariah dan Ridhawati. 2012. Kolonisasi Candida dalam Rongga Mulut. Majalah Kedokteran FK UKI 2012 Vol XXVIII No. 1. Departemen Parasitologi FK UI.

[9] Luthfi, M.; Arundina, I.; Hanmi, N. 2016. Inhibitory effect of jengkol leaf (Pithecellobium jiringa) extract to inhibit Candida albicans biofilm. Dental Journal (Majalah Kedokteran Gigi e-ISSN: 2442-9740. Accredited No. 56/DIKTI/Kep./2012.

[10] Mardiana, Lia. 2019. Optimasi Kombinasi Carbomer dan CMC Na dalam Sediaan Gel Pewarna Rambut Ekstrak Bunga Telang (Clitoria ternatea L.). Tesis. Universitas Setia Budi.

[11] Marlina dan Rosalini. 2017. Formulasi Pasta Gigi Gel Ekstrak Daun Sukun (Artocarpus Altilis) dengan Natrium CMC sebagai Gelling Agent dan Uji Kestabilan Fisiknya. JPP (Jurnal Kesehatan Palembang) Volume 12 No. 1 Juni 2017.

[12] Nurzaman, F.; Djajadisastra, J.; Elya, B. 2018. Identifikasi Kandungan Saponin dalam Ekstrak Kamboja Merah (Plumeria rubra L.) dan Daya Surfaktan dalam Sediaan Kosmetik. Jurnal Kefarmasian Indonesia. Vol. 8 No.2Agustus 2018.

[13] Ratnani, R.; Hartati, I.; Anas, Y.; Endah, D.; Khilyati, D. 2015. Standardisasi Spesifik dan Non Spesifik Ekstraksi Hidrotropi Andrographolid dari Sambiloto (Andrographis paniculata). Prosiding Seminar Nasional Peluang Herbal Sebagai Alternatif Medicine Tahun 2015. Fakultas Farmasi Universitas Wahid Hasyim.

[14] Sari, G.; Kuncahyo, I.; Rahayu, M. 2016. Optimasi Proporsi Polisorbat 80 dan Sorbitan 80 dalam Formulasi Krim Ekstrak Etil Asetat Daun Jengkol (Pithecollobium lobatum Benth) Sebagai Antibakteri dengan Metode Desain Faktorial. Jurnal Farmasi Indonesia, Maret 2016, Hal 71 – 81 Vol. 13 No. 1.

[15] Sari, N.; Anak, A.; Ni Luh U. 2019. Uji Aktivitas Antifungi Ekstrak Daun Kamboja Putih (Plumeria acuminata) terhadap Pertumbuhan Jamur Candida albicans. Jurnal Media Sains 3 (1): 28-31.

[16] Setiorini, M.; Soegiharjo, C.; Atmodjo, K. 2014. Potensi Antimikrobia Krim Ekstrak Ranting Patah Tulang (Euphorbia tirucalli Linn.) terhadap Propionibacterium acnes ATCC 11827 dan Candida albicans ATCC 24433. Jurnal Farmasi Sains Dan Komunitas, Vol. 11 No. 2, hlm. 64-71.

[17] Setyowati, H.; Hananun, Z.; Rr Putri, N.; Wahyuning, S. 2013. Krim Kulit Buah Durian (Durio zibethinus L.) sebagai Obat Herbal Pengobatan Infeksi Jamur Candida albicans. Media Farmasi Indonesia. Vol 8 No 2.

[18] Sogandi; Darma, W.; Jannah, R. 2019. Potensi Senyawa Antibakteri dari Ekstrak Akar Manis (Glycyrrhiza glabra L.) terhadap Bacillus cereus. Jurnal Kimia Sains dan Aplikasi. 22 (4) (2019): 105-111.

[19] Warnida, H.; Juliannor, A.; Sukawaty, Y. 2016. Formulasi Pasta Gigi Gel Ekstrak Etanol Bawang Dayak (Eleutherine bulbosa (Mill.) Urb.). Jurnal Sains dan Farmasi Klinis. Dipublikasikan 15 Nov 2016. e-ISSN: 2442-5435

[20] Zuhud. 2008. Potensi Hutan Tropika Indonesia sebagai Bahan Penyangga Bahan Obat Alam Untuk Kesehatan Bangsa. Fakultas Kehutanan Institut Pertanian Bogor.

[21] Zulfa, E.; Indah, F.; Murukmihadi, M. 2015. Optimasi Cmc-Na dan Karbomer sebagai Pengikat pada Formula Pasta Gigi Triklosan Secara SLD. Prosiding Seminar Nasional Peluang Herbal Sebagai Alternatif Medicine Tahun 2015. Fakultas Farmasi Universitas Wahid Hasyim.

[22] Zuniarto, Ahmad Azrul dan Tanujaya, Jojon. 2019. Uji Aktivitas Pasta Gigi Kitosan dari Limbah Kulit Udang sebagai Anti Jamur terhadap Candida albicans. Jurnal Farmasi dan Sains. Vol. 3 No. 1 2019.
Published
2021-04-22
How to Cite
Achsia, A. A., Kristijono, A., & Tilarso, D. P. (2021). Aktivitas Anti Candida albicans ATCC 14053 Sediaan Pasta Gigi Gel Ekstrak Daun Jengkol (Archidendron pauciflorum) dengan Kombinasi Na-CMC dan Karbomer. Jurnal Sains Dan Kesehatan, 3(2), 177-187. https://doi.org/10.25026/jsk.v3i2.267