Potensi Ekstrak Etanol Rimpang Jeringau (Acorus calamus L.) Sebagai Spasmolitik
DOI:
https://doi.org/10.25026/jsk.v1i7.53Keywords:
Acorus calamus, spasmolytic, ileum isolated organAbstract
Pain due to smooth muscle stiffness can occur in various circumstances of patients, ranging from normal circumstances such as menstrual pain, to a pathological condition of gastrointestinal infections. To overcome the pain it can be given medication to reduce muscle stiffness as spasmolytics, but there are side effects of the drug. Thus, the need for developing new spasmolytics drugs based on medicinal herbs with fewer side effects. This study was conducted to examine the potential of rhizome extract of jeringau (Acorus calamus L.) that is traditionally used by Dayak tribe to heal upset stomach. Spasmolytic activity of plant extracts tested with isolates organ methods of guinea pig ileum induced by histamine. Result of the study showed 0.3 mg/ml A. calamus rhizomes extract could decrease ileum contraction better than papaverine 0.03 mg/ml (p=0.00). The conclusion of this study is rhizome extract of jeringau (A. calamus) has the potential to be used as spasmolytics in treatment of health problems caused by smooth muscle contraction
References
[2]. Brunton LL, Lazo JS, Parker KL. (2006). Goodman and Gilman’s The Pharmacological Basis of Therapeutics. Eleventh edition. McGrawHill. New York.
[3]. Departemen Kesehatan RI. (2008). Farmakope Herbal Indonesia. Edisi Pertama. Departemen Kesehatan RI. Jakarta.
[4]. Ganjewala D, Srivastava AK. (2011). An update on chemical composition and bioactivities of Acorus species. Asian Journal of Plant Species. 10(3): 182-189.
[5]. Hitner H, Nagle B. (2012). Pharmacology An Introduction. Sixth Edition. McGraw Hill. New York.
[6]. Ismail S, Suwasono RA, Supriyoko W, Kuswanto H, Paryono P. (2015). Laporan Penelitian Riset Eksplorasi Pengetahuan Lokal Etnomedisin dan Tumbuhan Obat di Indonesia Berbasis Komunitas di Suku Abai, Kabupaten Malinau, Propinsi Kalimantan Utara. Badan Penelitian dan Pengembangan Kesehatan. Kementerian Kesehatan RI.
[7]. Katzung BG. (2009). Basic and Clinical Pharmacology. Eleventh Edition. McGraw-Hill. San Fransisco.
[8]. MIMS. (2016). MIMS Referensi Obat. Edisi Tujuh Belas. Bhuana Ilmu Populer. Jakarta.
[9]. Raini M, Isnawati A. (2016). Profile of Diare Medication Stored in Households in Indonesia Year 2013. Media Litbangkes. 26(4): 227-234.
[10]. Rajputa SB, Tongeb MB, Karuppayila SM. (2014). An overview on traditional uses and pharmacological profile of Acorus calamus Linn. (Sweet flag) and other Acorus species. Phytomedicine. 21: 268-276.
[11]. Singh R, Sharma PK, Malviya R. (2011). Pharmacological Properties and Ayurvedic Value of Indian Buch Plant (Acorus calamus): A Short Review. Advances in Biological Research. 5(3): 145-154.
[12]. The Plant List. (2013). Version 1.1. http://www.theplantlist.org
[13]. Trevor AJ, Katzung BG, Kruidering-Hall M, Masters SB. (2013). Pharmacology Examination and Board Review. Tenth Edition. McGraw Hill Medical. New York.
[14]. Vogel HG, Vogel WH. (1997). Drug discovery and evaluation: pharmacological assays. Chapter J: Activity of the gastrointestinal tract: Gut motility: Isolated ileum (MAGNUS technique). 496-498. Springer-Verlag. Berlin.
[15]. Yende SR, Harle UN, Rajgure DT, Tuse TA, Vyawahare NS. (2008). Pharmacological profile of Acorus calamus: An Overview. Pharmacognosy Reviews. 2(4): 22-26.
