Alkaloid Kuinolin dari Melicope denhamii dan Uji Aktivitas Antikankernya

  • Ratih Dewi Saputri
  • Tjitjik Srie Tjahjandarie Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, Indonesia
  • Mulyadi Tanjung Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, Indonesia
Keywords: Melicope denhamii, alkaloid kuinolin terisoprenilasi, sel P-388, antikanker

Abstract

Dua senyawa alkaloid kuinolin terisoprenilasi yakni N-metilflindersin (1) dan flindersin (2) telah diisolasi dari daun Melicope denhamii.  Struktur kedua senyawa ditetapkan berdasarkan analisis spektroskopi UV, IR, MS dan NMR. Uji aktivitas antikanker senyawa 12 terhadap murin leukemia P-388 memperlihatkan IC50 21,06 ± 0,85 dan 4,86 ± 0,30 µg/ml dan senyawa 2 mempunyai aktivitas moderat

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Published
2018-06-30
How to Cite
Saputri, R. D., Tjahjandarie, T. S., & Tanjung, M. (2018). Alkaloid Kuinolin dari Melicope denhamii dan Uji Aktivitas Antikankernya. Jurnal Sains Dan Kesehatan, 1(9), 505-509. https://doi.org/10.25026/jsk.v1i9.61