Pengaruh Minyak Biji Jinten Hitam (Nigella sativa L) terhadap Kadar Interleukin-4

Effect of Black Cumin Seed Oil (Nigella sativa L) on Interleukin-4 Level

Authors

  • Tantri Rachmayani Universitas Ahmad Dahlan Yogyakarta
  • Akrom Akrom Universitas Ahmad Dahlan, Jl. Prof.DR. Soepomo Sh, Warungboto Yogyakarta, 55164, Indonesia
  • Titiek Hidayati Universitas Muhammadiyah Yogyakarta, Jl. Brawijaya, Geblagan, Tamantirto, Kasihan Bantul Yogyakarta 5518, Indonesia

DOI:

https://doi.org/10.25026/jsk.v3i6.744

Keywords:

Black Cumin Seed Oil, Interleukin-4, active smokers

Abstract

Black cumin has a variety of efficacious substances, one of which is thymoquinon as an immunodulator, its role against Interleukin-4 with the subject of phase 2 clinical trials as an anti-inflammatory cytokine that is by inhibiting prostaglandin type E2 from arachidonic acid through induction resistance to cyclooxigenase-2. Aim to find out how the effect of Black Cumin Seed Oil in increasing levels of Interleukin-4. Randomized Clinical Trial study of 39 healthy participants of active smokers with the age of >18 years. Divided into 4 groups, namely Group 1 given placebo 3x1 capsules/day, group 2,3 and 4 given Black Cumin Seed Oil 3x1,3x2 and 3x3 capsules/day given for 30 days. Percentage il-4 using ELISA method. The results were analyzed using the One Way Annova method, with consecutive p-values (0.281 and 0.860) > 0.05 meaning there were meaningless differences between each treatment group. Based on the average percentage value of Interleukin-4, there was an increase in the MBJH treatment group of 3x1 capsules/day by 16,566% compared to the placebo group of 3x1 capsules/day by 13,995%.

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Published

2021-12-31

How to Cite

Rachmayani, T., Akrom, A., & Hidayati, T. (2021). Pengaruh Minyak Biji Jinten Hitam (Nigella sativa L) terhadap Kadar Interleukin-4 : Effect of Black Cumin Seed Oil (Nigella sativa L) on Interleukin-4 Level. Jurnal Sains Dan Kesehatan, 3(6), 773–780. https://doi.org/10.25026/jsk.v3i6.744