Uji Efek Tonikum Ekstrak Etanol Daun Pecut Kuda (Stachytarpheta jamaicensis L. Vahl) pada Mencit Putih Jantan (Mus musculus)
The Tonicum Effect of Ethanolic Extract of Stachytarpheta jamaicensis Leaves in White Mice Male (Mus musculus)
DOI:
https://doi.org/10.25026/jsk.v4i1.871Keywords:
Stachytarpheta jamaicensis, Tonicum effect.Abstract
Tonic is a substance that can increase the bodys defense system. The stimulant effect that is intertwined with the tonic effect is carried out by the central nervous system. Pecut kuda leaf and bases are useful as stimulants and tonics. This research aims to determine the tonicum effect of ethanolic extract pecut kuda leaf in mice. This was an experimental study with completely randomized group design, using male white mice and divided into five namely two control groups (K- given Na CMC 0,5% and K+ given 13 mg caffeine) and three treatment groups (ethanolic axtract of pecut kuda with a dose 50, 100 and 200 mg/kgBW) and each treatment group was repeated 5 times. The methods used were natatory exhaustion test, hanging test and sleep induction test for the parameters observed were the mice'defense on the surface of the water, the duration of the mice endurance on the hanging device and the time the mice fell asleep.The results of the observation data using Duncan's One Way ANNOVA test. The results showed that the pecut kuda leaf extract was effective against the tonic effect test at doses of 50, 100, 200 mg/kgBW. It can be said that pecut kuda leaf extract at a dose of 200 mg/kgBW has almost the same effect as K+ (13mg caffeine).
References
[2] Dalimartha, “Atlas tumbuhan obat indonesia jilid 2-141230182645-Conversion-Gate01.Pdf.” 2000.
[3] J. L. C. . Van valkenbutg and N. Bunyapraphatsara, Plant resources of south-east Asia 12 (2): medicinal and poisonous plants 2, vol. 81, no. 1. 2002.
[4] K. Bone and S. Mills, Principles and Practice of Phytoterapy. New York, 2000.
[5] K. Utami, I. Sari, and Nurhafidhah, “Pengaruh Pemberian Topikal Ekstrak Etanol Daun Pecut Kuda (Stachytarpheta jamaicensis (L.) Vahl) Terhadap Penyembuhan Luka Terbuka Pada Punggung Mencit (Mus musculus),” pedidikan Kim. dan ilmu Kim., vol. 2, no. 1, pp. 21–27, 2019.
[6] S. Duret, H. Jacquemin, and R. R. Paris, “Plantes Malgaches No Xix. Sur La Composition Chimique De Stachytarpheta Jamaicensis (L) Vahl( = S. Indica Vahl), Verbenacees,” Plantes Med. Phyther., vol. 10, no. 2, pp. 96–104, 1976.
[7] N. Koirala, R. P. Pandey, P. P. Arajuli, H.J.Jung, and J. K. Sohng, “Methylation and subsequent glycosylation of 7,8-dihydroxy?avone,” J. Biotechnol., vol. 184, no. 1, 2014,[Online].Available:https://www.academia.edu/25229835/Methylation_and_subsequent_glycosylation_of_7_8_dihydroxyflavone.
[8] E. Mailisdiani and L. M. Santoso, “Efek Tonik Ekstrak Daun Kenikir (Cosmos caudatus Kunth .) Terhadap Mencit (Mus musculus) Galur Swiss Webster Serta Sumbangannya Pada Pembelajaran Biologi SMA,” Pembelajaran Biol., vol. 03, no. 02, pp. 190–199, 2016.
[9] S. Suhirman, “Skrining Fitokimia pada Beberapa Jenis Pecut Kuda ( Stachytarpheta jamaicensis L . Vahl ),” Pros. Semin. Nas., no. April, pp. 93–97, 2015.
[10] A. A. Mamung and P. Astuti, “Standarisasi Simplisia Dan Ekstrak Daun Pecut Kuda ( Stachytarpheta jamaicensis ( L ) Vahl ) Dari Kabupaten Manggarai Nusa Tenggara Timur / Flores,” Akad. Farm. Putra Indones. Malang, pp. 1–8, 2019, [Online]. Available: http://repository.poltekkespim.ac.id/id/eprint/481/.
[11] D. RI, Farmakope Herbal Indonesia, 1st ed. Jakarta: Departemen Kesehatan Republik Indonesia, 2008.
[12] D. RI, Parameter Standar Umum Ekstrak Tumbuhan Obat, 1st ed. Jakarta: Departemen Kesehatan Republik Indonesia, 2000.
[13] D. Febriani, D. Mulyanti, and E. Rismawati, “Karakterisasi Simplisia dan Ekstrak Etanol Daun Sirsak (Annona muricata Linn),” Pros. Penelit. Spes. Unisba, pp. 475–480, 2015.
[14] F. Sani K, Y. Yuliawati, H. Herlina, and R. Yolandini, “Uji efek tonikum ekstrak daun sawo manila (Manilkara zapota) pada mencit putih jantan (Mus musculus) dengan metode ketahanan renang,” Ris. Inf. Kesehat., vol. 9, no. 1, p. 37, 2020, doi: 10.30644/rik.v9i1.267.
[15] R. Pratiwi, R. Tjahyadi, and Chusun, “Uji Efek Tonikum Ekstrak Etanol Herba Pegagan (Centella asiatica (L). Urb) Pada Mencit Jantan Balb/C,” Fitofarmaka, vol. 38, no. 3, pp. 105–119, 2015.
[16] H. m Mafitri and A. Parmadi, “Uji Efek Tonikum Ekstrak Etanol Daun Pandan Wangi ( Pandanus amaryllifolius Roxb .) terhadap Mencit dengan Metode Natatory Exhaustion,” Indones. J. Med. Sci., vol. 5, no. 1, pp. 64–69, 2018.
[17] R. A. Turner, Screening Methods In Pharmacology. Academic Press, 1965.
[18] Z. R. Suhatri, Yimmi Syavardie, “Aktifitas Stimulan Sistim Saraf Pusat Ekstrak Biji Pinang ( Areca Catechu, L ) Terhadap Mencit Putih ( Mus Musculus, L),” Kesehatan, vol. 3, no. 1, pp. 22–27, 2011.
[19] M. Aria, S. T. J. Fendri, and H. Muqaddar, “Uji Efek Stimulan Sistem Saraf Pusat Ekstrak Etanol Daun Pegagan (Centella asiatica(L.) Urban ) Terhadap Mencit Putih Betina,” J. Farm. dan Kesehat., vol. 7, no. 1, p. 35, 2017, doi: 10.36434/scientia.v7i1.103.
[20] E. Mutschler, Dinamika Obat Farmakologi dan Toksikologi, 5th ed. Bandung: ITB, 1991.
[21] J. M. Davis, Z. Zhao, H. S. Stock, K. A. Mehl, J. Buggy, and G. A. Hand, “Central nervous system effects of caffeine and adenosine on fatigue,” Am. J. Physiol. - Regul. Integr. Comp. Physiol., vol. 284, no. 2 53-2, pp. 399–404, 2003, doi: 10.1152/ajpregu.00386.2002.
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