Alkaloid Furokuinolin dan Asam Sinamat Ter-O-Geranilasi dari Kulit Batang Melicope hookeri T.G. HARTLEY

  • Ratih Dewi Saputri Lab. Kimia Organik Bahan Alam, Departemen Kimia, Fakultas Sains dan Teknologi, Universitas Airlangga, Surabaya 60115, Indonesia
  • Tjitjik Srie Tjahjandarie Lab. Kimia Organik Bahan Alam, Departemen Kimia, Fakultas Sains dan Teknologi, Universitas Airlangga, Surabaya 60115, Indonesia
  • Mulyadi Tanjung Departemen Kimia, Fakultas Sains dan Teknologi, Universitas Airlangga, Surabaya 60115, Indonesia
Keywords: Melicope hookeri, furokuinoline alkaloid, cinnamate acid, , anticancer

Abstract

One furokuinoline alkaloid, evolitrine (1), and one cinnamate acid, trans 3-methyl-4-geranil caffeic acid (2) were isolated from  the stem bark of Melicope hookeri.  The structures of both compounds were determined  based on spectroscopic data such as UV, IR, MS and NMR. Compounds 12 were evaluated for their anticancer activity against murin leukemia P-388 cells, showing their IC50 were 4,06 ± 0,15 and 4,86 ± 0,30 µg/ml, and two compounds showed moderate activity.

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Published
2019-06-30
How to Cite
Saputri, R. D., Tjahjandarie, T. S., & Tanjung, M. (2019). Alkaloid Furokuinolin dan Asam Sinamat Ter-O-Geranilasi dari Kulit Batang Melicope hookeri T.G. HARTLEY. Jurnal Sains Dan Kesehatan, 2(1), 1-7. https://doi.org/10.25026/jsk.v2i1.93