Pengaruh Pemberian Minyak Ikan terhadap Hasil Terapi Pasien Skizofrenia Rawat Inap Berdasarkan Skala PANSS

The Effect of Fish Oil Administration on the Therapeutic Outcome of Schizophrenic Inpatients Based on the PANSS Scale

Authors

  • Warrantia Citta Citti Putri Program Studi Farmasi, Fakultas Humaniora dan Kesehatan, Universitas Mulia, Balikpapan, Indonesia
  • Nishia Waya Meray Program Studi Farmasi, Fakultas Humaniora dan Kesehatan, Universitas Mulia, Balikpapan, Indonesia
  • Indah Woro Utami Program Studi Farmasi, Fakultas Humaniora dan Kesehatan, Universitas Mulia, Balikpapan, Indonesia

Keywords:

Minyak ikan, Skizofrenia, Randomized Control Trial

Abstract

Pemberian minyak ikan sebagai terapi tambahan skizofrenia dapat menurunkan nilai Positive and Negative Syndrome Scale (PANSS) pada pasien rawat inap di Rumah Sakit Grhasia. Penelitian cross sectional dilakukan dengan pre-test and post-test with control group design, minyak ikan diberikan 2 kali sehari 1 kapsul selama 6 minggu dan skala PANSS digunakan untuk menilai efektifitas terapi. Untuk pengambilan sampel diambil menggunakan metode consecutive sampling dan data yang diperoleh akan dianalisis menggunakan uji-t berpasangan. Hasil penelitian menunjukkan rata-rata 50 poin pada 22 kelompok perlakuan dan rata-rata penurunan sebesar 39,4 poin pada 22 kelompok kontrol. Dapat disimpulkan pemberian minyak ikan sebagai terapi tambahan dalam pengobatan pasien skizofrenia akan memberikan hasil terapi yang lebih baik daripada tidak diberikan tambahan minyak ikan.

References

[1] S. Zahnia and D. Wulan Sumekar, “Kajian Epidemiologis Skizofrenia,” Majority, vol. 5, no. 5, pp. 160–166, 2016.
[2] P. Bozzatello, E. Brignolo, E. De Grandi, and S. Bellino, “Supplementation with Omega-3 Fatty Acids in Psychiatric Disorders: A Review of Literature Data,” J. Clin. Med., 2016.
[3] M. E. Berger et al., “Omega-6 to omega-3 polyunsaturated fatty acid ratio and subsequent mood disorders in young people with at-risk mental states: A 7-year longitudinal study,” Transl. Psychiatry, vol. 7, no. June, pp. 1–6, 2017.
[4] K. Satogami, S. Takahashi, S. Yamada, S. Ukai, and K. Shinosaki, “Omega-3 fatty acids related to cognitive impairment in patients with schizophrenia,” Schizophr. Res. Cogn., vol. 9, no. January, pp. 8–12, 2017.
[5] P. Bozzatello, M. L. De Rosa, P. Rocca, and S. Bellino, “Effects of omega 3 fatty acids on main dimensions of psychopathology,” Int. J. Mol. Sci., vol. 21, no. 17, pp. 1–29, 2020.
[6] M. J. Obermeier, “The Positive and Negative Syndrome Scale for Schizophrenia?: An Established Rating Instrument in Need of Clarification,” Dissertation, 2012.
[7] M. Obermeier et al., “Is the PANSS used correctly? A systematic review,” BMC Psychiatry, 2011.
[8] A. Triyono, “Newsletter PTTK&EK,” War. LPM, vol. 1, no. 13, pp. iii–v, 2012.
[9] M. Areda, “The role of omega-3 fatty acids in the treatment of schizophrenia through modification of membrane phospholipids,” Thesis, p. 50, 2016.
[10] K. Akter et al., “A review of the possible role of the essential fatty acids and fish oils in the aetiology, prevention or pharmacotherapy of schizophrenia,” J. Clin. Pharm. Ther., vol. 37, no. 2, pp. 132–139, 2012.
[11] N. Balasubramanian, “Omega 3 Fatty Acids: An Adjunct for Schizophrenia,” Int. J. Heal. Sci. Res., vol. 3, no. February, pp. 1–6, 2013.
[12] H. Jamilian, H. Solhi, and M. Jamilian, “Randomized, placebo-controlled clinical trial of omega-3 as supplemental treatment in schizophrenia,” Glob. J. Health Sci., vol. 6, no. 7, pp. 103–108, 2014.
[13] M. C. Hsu, Y. S. Huang, and W. C. Ouyang, “Beneficial effects of omega-3 fatty acid supplementation in schizophrenia: Possible mechanisms,” Lipids Health Dis., vol. 19, no. 1, pp. 1–17, 2020.
[14] A. I. Zugno et al., “Effects of omega-3 supplementation on interleukin and neurotrophin levels in an animal model of schizophrenia,” An. Acad. Bras. Cienc., vol. 87, no. 2, pp. 1475–1486, 2015.
[15] G. Grosso et al., “Role of omega-3 fatty acids in the treatment of depressive disorders: A comprehensive meta-analysis of randomized clinical trials,” PLoS One, vol. 9, no. 5, 2014.
[16] R. P. Patrick and B. N. Ames, “Vitamin D and the omega-3 fatty acids control serotonin synthesis and action, part 2: Relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior,” FASEB J., vol. 29, no. 6, pp. 2207–2222, 2015.

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Published

2021-12-31

How to Cite

Putri, W. C. C., Meray, N. W., & Utami, I. W. (2021). Pengaruh Pemberian Minyak Ikan terhadap Hasil Terapi Pasien Skizofrenia Rawat Inap Berdasarkan Skala PANSS: The Effect of Fish Oil Administration on the Therapeutic Outcome of Schizophrenic Inpatients Based on the PANSS Scale . Jurnal Sains Dan Kesehatan, 3(6), 795–800. Retrieved from https://jsk.farmasi.unmul.ac.id/index.php/jsk/article/view/933