Pengaruh SSRIs Untuk Meningkatkan Independensi Fungsional Pada Pasien Depresi Pasca Stroke
Effect of SSRIs to Improve Functional Independence in Post-Stroke Depression Patients
DOI:
https://doi.org/10.25026/jsk.v3i3.280Keywords:
SSRI, Functional independence, Post-stroke depression, effectAbstract
Post-stroke depression has a negative impact on the functional independence of patients carrying out daily activities. Selective serotonin reuptake inhibitors (SSRIs) are a class of antidepressants that are recommended as the first-line therapy for post-stroke depression because of their favorable tolerability profile. This literature review is intended to present a new insight about the effect of SSRIs in increasing the functional independence in patients with post-stroke depression. We applied a qualitative research design using two notable databases: PubMed and Google Scholar. Only references written in English were used in this paper. We also limited the publication year of journals from 2010 to 2020. From the results of journal searches, we found around 52.984 journals. However only 5 were included that met the inclusion criteria which were: (1), Randomized Controlled Trial (RCT) that tested the benefits of SSRIs treatment in post-stroke depression patients compared to other antidepressants or other treatment modalities; and (2) provided with the outcome measure of functional independence. In conclusion, we believe that SSRIs have an effect on improving functional independence in post-stroke depression patients. SSRIs have also been shown to have positive effects with various combinations of non-pharmacological therapeutic modalities as their support.
References
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8. Guajardo VD, Terroni L, Sobreiro MDFM, Zerbini MIDS, Tinone G, Scaff M, et al. The influence of depressive symptoms on quality of life after stroke: A prospective study. J Stroke Cerebrovasc Dis. 2015;24(1):201–9.
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11. Stokes&Hasan. Depression after stroke: A review of the evidence base to inform the development of an integrated care pathway. Part 2: Treatment alternatives. Clin Rehabil. 2002;16(3):248–60.
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15. Gu SC, Wang C De. Early Selective Serotonin Reuptake Inhibitors for Recovery after Stroke: A Meta-Analysis and Trial Sequential Analysis. J Stroke Cerebrovasc Dis [Internet]. 2018;27(5):1178–89. Available from: https://doi.org/10.1016/j.jstrokecerebrovasdis.2017.11.031
16. Kraglund KL, Mortensen JK, Grove EL, Johnsen SP, Andersen G. TALOS: A multicenter, randomized, double-blind, placebo-controlled trial to test the effects of citalopram in patients with acute stroke. Int J Stroke. 2015;10(6):985–7.
17. Hong W, Zhao Z, Wang D, Li M, Tang C, Li Z, et al. Altered gray matter volumes in post-stroke depressive patients after subcortical stroke. NeuroImage Clin [Internet]. 2020;26(September 2019):102224. Available from: https://doi.org/10.1016/j.nicl.2020.102224
18. Chemerinski et al. Improved recovery in activities of daily living associated with remission of poststroke depression. Stroke. 2001;32(1):113–7.
19. Zhou S, Liu S, Liu X, Zhuang W. Selective serotonin reuptake inhibitors for functional independence and depression prevention in early stage of post-stroke: A meta-analysis. Med (United States). 2020;99(6):1–8.
20. Kwon CY, Lee B, Chung SY, Kim JW, Shin A, Choi Y yong, et al. Efficacy and safety of Sihogayonggolmoryeo-tang (Saikokaryukotsuboreito, Chai-Hu-Jia-Long-Gu-Mu-Li-Tang) for post-stroke depression: A systematic review and meta-analysis. Sci Rep. 2019;9(1):1–20.
21. Mikami K, Jorge RE, Adams HP, Davis PH, Leira EC, Jang M, et al. Effect of antidepressants on the course of disability following stroke. Am J Geriatr Psychiatry [Internet]. 2011;19(12):1007–15. Available from: http://dx.doi.org/10.1097/JGP.0b013e31821181b0
22. Schmidt HD, Duman RS. The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior. Behav Pharmacol. 2007;18(5–6):391–418.
23. Imran et al. Efektifitas New Bobath Concept Terhadap Peningkatan Fungsional Pasien Stroke Iskemik dengan Outcome Stroke Diukur Menggunakan Fungsional Independent Measurement ( Fim ) dan Glasgow Outcome Scale ( GOS ) Di RSUDZA 2018. J Med Sci. 2020;1(1):14–20.
24. Kim et al. Efficacy of early administration of escitalopram on depressive and emotional symptoms and neurological dysfunction after stroke: a multicentre, double-blind, randomised, placebo-controlled study. The Lancet Psychiatry [Internet]. 2017;4(1):33–41. Available from: http://dx.doi.org/10.1016/S2215-0366(16)30417-5
25. Robinson et al. Clinical Neuropsychiatry of Stroke. 2006;
26. Gao J, Lin M, Zhao J, Bi S, Ni Z, Shang X. Different interventions for post-ischaemic stroke depression in different time periods: A single-blind randomized controlled trial with stratification by time after stroke. Clin Rehabil. 2017;31(1):71–81.
27. Lanctôt KL, Lindsay MP, Smith EE, Sahlas DJ, Foley N, Gubitz G, et al. Canadian Stroke Best Practice Recommendations: Mood, Cognition and Fatigue following Stroke, 6th edition update 2019. Int J Stroke. 2019;0(0):1–21.
28. Man S, Hung BHB, Ng RMK, Yu X, Cheung H, Fung MPM, et al. A pilot controlled trial of a combination of dense cranial electroacupuncture stimulation and body acupuncture for post-stroke depression. 2014;1–8.
29. Razazian N, Esmaeili O, Almasi A. Effect of Fluoxetine on Motor Improvement in Ischemic Stroke Patients: A Double Blind Clinical Trial Study. Zahedan J Res Med Sci. 2016;18(7).
30. Miyai I, Reding MJ. Effects of Antidepressants on Functional Recovery Following Stroke: A Double-Blind Study. Neurorehabil Neural Repair. 1998;12(1):5–13.
31. Gonzalez-Torrecillas JL, Mendlewicz J, Lobo A. Effects of Early Treatment of Poststroke Depression on Neuropsychological Rehabilitation. Int Psychogeriatrics. 1995;7(4):547–60.
32. Gainotti G, Antonucci G, Marra C, Paolucci S. Relation between depression after stroke, antidepressant therapy, and functional recovery. J Neurol Neurosurg Psychiatry. 2001;71(2):258–61.
33. Loubinoux I, Pariente J, Boulanouar K, Carel C, Manelfe C, Rascol O, et al. A single dose of the serotonin neurotransmission agonist paroxetine enhances motor output: Double-blind, placebo-controlled, fMRI study in healthy subjects. Neuroimage. 2002;15(1):26–36.
34. Pariente J, Loubinoux I, Carel C, Albucher JF, Leger A, Manelfe C, et al. Fluoxetine modulates motor performance and cerebral activation of patients recovering from stroke. Ann Neurol. 2001;50(6):718–29.
35. Stamenkovic et al. Poststroke Depression and Fluoxetine. 1996;(March):446–7.
36. Zhaosheng D, Fang Z, Maming LIN, Yun W. Effect of Fluoxetine on Expression of Brain- derived Neurotrophic Factor in Patients with Post-stroke Depression. 2014;2(4):467–71.
2. Castilla-Guerra L, Fernandez Moreno M del C, Esparrago-Llorca G, Colmenero-Camacho MA. Pharmacological management of post-stroke depression. Expert Rev Neurother [Internet]. 2020;20(2):157–66. Available from: https://doi.org/10.1080/14737175.2020.1707666
3. Espárrago Llorca G, Castilla-Guerra L, Fernández Moreno MC, Ruiz Doblado S, Jiménez Hernández MD. Depresión post ictus: Una actualización. Neurologia [Internet]. 2015;30(1):23–31. Available from: http://dx.doi.org/10.1016/j.nrl.2012.06.008
4. Berg A, Palomäki H, Lehtihalmes M, Lönnqvist J, Kaste M. Poststroke depression in acute phase after stroke. Cerebrovasc Dis. 2001;12(1):14–20.
5. Vika WN, Syarifah AS, Ratnawati M. Hubungan Status Fungsional Dengan Tingkat Depresi Pada Pasien Stroke Di Ruang Flamboyan Rsud Jombang. J Ilm Kebidanan (Scientific J Midwifery). 2018;4(1):52–9.
6. Khomsiatun. Hubungan status fungsional terhadap depresi pada pasien stroke di ruang fisioterapi di rsud wilayah kabupaten semarang. 2015;
7. Feng C, Fang M, Liu XY. The neurobiological pathogenesis of poststroke depression. Sci World J. 2014;2014.
8. Guajardo VD, Terroni L, Sobreiro MDFM, Zerbini MIDS, Tinone G, Scaff M, et al. The influence of depressive symptoms on quality of life after stroke: A prospective study. J Stroke Cerebrovasc Dis. 2015;24(1):201–9.
9. Cai W, Mueller C, Li YJ, Shen WD, Stewart R. Post stroke depression and risk of stroke recurrence and mortality: A systematic review and meta-analysis. Ageing Res Rev [Internet]. 2019;50:102–9. Available from: https://doi.org/10.1016/j.arr.2019.01.013
10. Dar et al. Post Stroke Depression Frequently Overlooked, Undiagnosed, Untreated. Neuropsychiatry (London). 2017;07(06):906–19.
11. Stokes&Hasan. Depression after stroke: A review of the evidence base to inform the development of an integrated care pathway. Part 2: Treatment alternatives. Clin Rehabil. 2002;16(3):248–60.
12. Gruenbaum BF, Kutz R, Zlotnik A. Blood glutamate scavenging sebagai pendekatan terapi berbasis glutamat baru untuk depresi pasca-stroke. 2020;0:1–14.
13. Chollet F, Tardy J, Albucher JF, Thalamas C, Berard E, Lamy C, et al. Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): A randomised placebo-controlled trial. Lancet Neurol [Internet]. 2011;10(2):123–30. Available from: http://dx.doi.org/10.1016/S1474-4422(10)70314-8
14. Savadi Oskouie D, Sharifipour E, Sadeghi Bazargani H, Hashemilar M, Nikanfar M, Ghazanfari Amlashi S, et al. Efficacy of Citalopram on Acute Ischemic Stroke Outcome: A Randomized Clinical Trial. Neurorehabil Neural Repair. 2017;31(7):638–47.
15. Gu SC, Wang C De. Early Selective Serotonin Reuptake Inhibitors for Recovery after Stroke: A Meta-Analysis and Trial Sequential Analysis. J Stroke Cerebrovasc Dis [Internet]. 2018;27(5):1178–89. Available from: https://doi.org/10.1016/j.jstrokecerebrovasdis.2017.11.031
16. Kraglund KL, Mortensen JK, Grove EL, Johnsen SP, Andersen G. TALOS: A multicenter, randomized, double-blind, placebo-controlled trial to test the effects of citalopram in patients with acute stroke. Int J Stroke. 2015;10(6):985–7.
17. Hong W, Zhao Z, Wang D, Li M, Tang C, Li Z, et al. Altered gray matter volumes in post-stroke depressive patients after subcortical stroke. NeuroImage Clin [Internet]. 2020;26(September 2019):102224. Available from: https://doi.org/10.1016/j.nicl.2020.102224
18. Chemerinski et al. Improved recovery in activities of daily living associated with remission of poststroke depression. Stroke. 2001;32(1):113–7.
19. Zhou S, Liu S, Liu X, Zhuang W. Selective serotonin reuptake inhibitors for functional independence and depression prevention in early stage of post-stroke: A meta-analysis. Med (United States). 2020;99(6):1–8.
20. Kwon CY, Lee B, Chung SY, Kim JW, Shin A, Choi Y yong, et al. Efficacy and safety of Sihogayonggolmoryeo-tang (Saikokaryukotsuboreito, Chai-Hu-Jia-Long-Gu-Mu-Li-Tang) for post-stroke depression: A systematic review and meta-analysis. Sci Rep. 2019;9(1):1–20.
21. Mikami K, Jorge RE, Adams HP, Davis PH, Leira EC, Jang M, et al. Effect of antidepressants on the course of disability following stroke. Am J Geriatr Psychiatry [Internet]. 2011;19(12):1007–15. Available from: http://dx.doi.org/10.1097/JGP.0b013e31821181b0
22. Schmidt HD, Duman RS. The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior. Behav Pharmacol. 2007;18(5–6):391–418.
23. Imran et al. Efektifitas New Bobath Concept Terhadap Peningkatan Fungsional Pasien Stroke Iskemik dengan Outcome Stroke Diukur Menggunakan Fungsional Independent Measurement ( Fim ) dan Glasgow Outcome Scale ( GOS ) Di RSUDZA 2018. J Med Sci. 2020;1(1):14–20.
24. Kim et al. Efficacy of early administration of escitalopram on depressive and emotional symptoms and neurological dysfunction after stroke: a multicentre, double-blind, randomised, placebo-controlled study. The Lancet Psychiatry [Internet]. 2017;4(1):33–41. Available from: http://dx.doi.org/10.1016/S2215-0366(16)30417-5
25. Robinson et al. Clinical Neuropsychiatry of Stroke. 2006;
26. Gao J, Lin M, Zhao J, Bi S, Ni Z, Shang X. Different interventions for post-ischaemic stroke depression in different time periods: A single-blind randomized controlled trial with stratification by time after stroke. Clin Rehabil. 2017;31(1):71–81.
27. Lanctôt KL, Lindsay MP, Smith EE, Sahlas DJ, Foley N, Gubitz G, et al. Canadian Stroke Best Practice Recommendations: Mood, Cognition and Fatigue following Stroke, 6th edition update 2019. Int J Stroke. 2019;0(0):1–21.
28. Man S, Hung BHB, Ng RMK, Yu X, Cheung H, Fung MPM, et al. A pilot controlled trial of a combination of dense cranial electroacupuncture stimulation and body acupuncture for post-stroke depression. 2014;1–8.
29. Razazian N, Esmaeili O, Almasi A. Effect of Fluoxetine on Motor Improvement in Ischemic Stroke Patients: A Double Blind Clinical Trial Study. Zahedan J Res Med Sci. 2016;18(7).
30. Miyai I, Reding MJ. Effects of Antidepressants on Functional Recovery Following Stroke: A Double-Blind Study. Neurorehabil Neural Repair. 1998;12(1):5–13.
31. Gonzalez-Torrecillas JL, Mendlewicz J, Lobo A. Effects of Early Treatment of Poststroke Depression on Neuropsychological Rehabilitation. Int Psychogeriatrics. 1995;7(4):547–60.
32. Gainotti G, Antonucci G, Marra C, Paolucci S. Relation between depression after stroke, antidepressant therapy, and functional recovery. J Neurol Neurosurg Psychiatry. 2001;71(2):258–61.
33. Loubinoux I, Pariente J, Boulanouar K, Carel C, Manelfe C, Rascol O, et al. A single dose of the serotonin neurotransmission agonist paroxetine enhances motor output: Double-blind, placebo-controlled, fMRI study in healthy subjects. Neuroimage. 2002;15(1):26–36.
34. Pariente J, Loubinoux I, Carel C, Albucher JF, Leger A, Manelfe C, et al. Fluoxetine modulates motor performance and cerebral activation of patients recovering from stroke. Ann Neurol. 2001;50(6):718–29.
35. Stamenkovic et al. Poststroke Depression and Fluoxetine. 1996;(March):446–7.
36. Zhaosheng D, Fang Z, Maming LIN, Yun W. Effect of Fluoxetine on Expression of Brain- derived Neurotrophic Factor in Patients with Post-stroke Depression. 2014;2(4):467–71.
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Published
2021-06-30
How to Cite
Salim, W. P., Hutahaean, Y. O., & Sihotang, F. A. . (2021). Pengaruh SSRIs Untuk Meningkatkan Independensi Fungsional Pada Pasien Depresi Pasca Stroke: Effect of SSRIs to Improve Functional Independence in Post-Stroke Depression Patients. Jurnal Sains Dan Kesehatan, 3(3), 529–537. https://doi.org/10.25026/jsk.v3i3.280
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