Formulasi dan Karakterisasi Nanopartikel Kitosan Ekstrak Sari Buah Juwet (Syzygium cumini) menggunakan metode Gelasi Ionik
Formulation and characterization of Chitosan Nanoparticle of Juwet (Syzygium cumini) Fruit Extract Using Ionic Gelation Method
DOI:
https://doi.org/10.25026/jsk.v3i5.614Keywords:
Chitosan, Ionic gelation, Nanoparticle, Syzygium cumini.Abstract
Syzygium cumini (S. cumini) fruits have a high potential to be developed as medicine because of their polyphenol content. Polyphenol is easily degraded so that its stability needs to be increased through the formation of nanoencapsulation. The aim of this study was to determine the formula of SBJ nanoparticles which has good characteristics. The formula was determined using a pseudoternary phase diagram based on the %transmittant and %EE. Nano SBJ was characterized for % transmittant ,% EE, polydispersity index, and zeta potential. The formula of Nano SBJ obtained chitosan, SBJ extract, and Na TPP were 0.347%, 0.627%, and 0.047%, respectively. The characterization of Nano SBJ were % EE was 30.72%, the mean diameter of particles was 138.1 ± 7.9 nm, PdI was 0.839 ± 0.043, and zeta potential was 34.9 ± 1.2 mV. Nano SBJ has nano-sized particles and has good stability, but low in entrapment efficiency.
References
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[3] R. Gupta and A. M. Saxena, “Hypoglycemic and Anti-hyperglycemic Activities of Syzygium cumini (Linn.) Skeels Whole Fruit, in Normal and Streptozotocin-Induced Diabetic Rats,” Asian Journal of Pharmaceutical and Biological Research, vol. 1, no. 3, p. 7.
[4] A. E.-M. M. Afify, S. A. Fayed, E. A. Shalaby, and H. A. El-Shemy, “Syzygium cumini (pomposia) active principles exhibit potent anticancer and antioxidant activities,” African Journal of Pharmacy and Pharmacology, vol. 5, no. 7, pp. 948–956.
[5] M. Ayyanar and P. Subash-Babu, “Syzygium cumini (L.) Skeels: A review of its phytochemical constituents and traditional uses,” Asian Pacific Journal of Tropical Biomedicine, vol. 2, no. 3, pp. 240–246.
[6] A. Banerjee, N. Dasgupta, and B. De, “In vitro study of antioxidant activity of fruit,” Food Chemistry, vol. 90, no. 4, pp. 727–733.
[7] J. P. Singh et al., “In vitro antioxidant and antimicrobial properties of jambolan (Syzygium cumini) fruit polyphenols,” LWT - Food Science and Technology, vol. 65, pp. 1025–1030.
[8] B. Chaudhary and K. Mukhopadhyay, “Syzygium cumini (L.) skeel?: a potential source of nutraceuticals,” International Journal of Pharmacy and Biological Sciences, vol. 2, no. 1, pp. 46–53.
[9] J. Veigas, M. Narayan, P. Laxman, and B. Neelwarne, “Chemical nature, stability and bioefficacies of anthocyanins from fruit peel of syzygium cumini Skeels,” Food Chemistry, vol. 105, no. 2, pp. 619–627.
[10] R. K. Bijauliya, S. Alok, M. Singh, and S. B. Mishra, “Morphology, phytochemistry and pharmacology of Syzygium cumini (Linn.) - an overview,” International Journal of Pharmaceutical Sciences and Research, vol. 8, no. 6, pp. 2360–2371.
[11] S. Ramya, K. Neethirajan, and R. Jayakumararaj, “Profile of bioactive compounds in Syzygium cumini – a review,” Journal of Pharmacy Research, no. 8, p. 7.
[12] V. Thorat, “Syzygium cumini?: a review,” International Journal of Pharmacognosy, vol. 4, no. 10, pp. 320–331.
[13] B. Singh, J. P. Singh, A. Kaur, and N. Singh, “Insights into the phenolic compounds present in jambolan (Syzygium cumini) along with their health-promoting effects,” International Journal of Food Science & Technology, vol. 53, no. 11, pp. 2431–2447.
[14] A. Liazid, M. Palma, J. Brigui, and C. G. Barroso, “Investigation on phenolic compounds stability during microwave-assisted extraction,” Journal of Chromatography A, vol. 1140, no. 1–2, pp. 29–34.
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[16] W. Hajrin, “Formulasi Mikropartikel Ekstrak Etanol Herba Meniran (Phyllanthus niruri) Menggunakan Polimer Kitosan dan Na-TPP Serta Uji Aktivitas Imunomodulator Secara In Vivo,” Tesis, Universitas Gadjah Mada Yogyakarta.
[17] G. Pratiwi, R. Martien, and R. Murwanti, “Chitosan nanoparticle as a delivery system for polyphenols from meniran extract (Phyllanthus niruri L)?: formulation, optimization, and immunomodulatory activity,” Int J App Pharm, pp. 50–58.
[18] M. George and T. E. Abraham, “Polyionic hydrocolloids for the intestinal delivery of protein drugs: Alginate and chitosan — a review,” Journal of Controlled Release, vol. 114, no. 1, pp. 1–14.
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[20] W. Tiyaboonchai, “Chitosan Nanoparticles: A Promising System for Drug Delivery,” Naresuan University Journal, vol. 11, no. 3, pp. 51–66.
[21] P. D. Apsari and H. Susanti, “Perbandingan kadar fenolik total ekstrak metanol kelopak merah dan ungu bunga rosella,” p. 6.
[22] P. Hariyadi, “Pengeringan beku dan aplikasinya di industri pangan,” Food Review, vol. 8, no. 1, pp. 52–56.
[23] J. Suryadi, “Daya antioksidan ekstrak etanol kulit buah manggis (Garcinia mangostana L.) pengeringan matahari langsung dan freeze- drying,” Jurnal Ilmiah Mahasiswa Universitas Surabaya, vol. 2, no. 1, pp. 1–19.
[24] B. B. Sembiring, “garuh konsentrasi bahan pengisi dan cara pengeringan terhadapmutu ekstrak kering sambiloto,” Buletin Penelitian Tanaman Rempah dan Obat, vol. 20, no. 2.
[25] R. Alfian and H. Susanti, “Penetapan kadar fenolik total ekstrak metanol kelopak bunga rosella merah (Hibiscus sabdariffa Linn) dengan variasi tempat tumbuh secara spektrofometri,” Jurnal Ilmiah Kefarmasian, vol. 2, no. 1, pp. 73–80.
[26] E. H. Imad, M. Didi, F. Bekkara, and M. Gherib, “In vitro antioxidant activity and total phenolic contents in methanol crude extracts from the Algerian medicinal plant Limoniastrum feei,” Scientific Study and Research, vol. 10, no. 4, pp. 329–336.
[27] M. Sahumena, “Pengembangan nanopartikel ketoprofen dengan teknik SNEDDS dan uji aktifitas antiinflamasi,” Tesis, vol. Yogyakarta?:Program Pasca Sarjana Universitas Gadjah Mada.
[28] S. Arora and R. D. Budhiraja, “Chitosan-alginate microcapsules of amoxicillin for gastric stability and mucoadhesion,” J Adv Pharm Technol Res, vol. 3, no. 1, pp. 68–74.
[29] J. Berger, M. Reist, J. M. Mayer, O. Felt, N. A. Peppas, and R. Gurny, “Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 57, no. 1, pp. 19–34.
[30] K. Dupinder and S. Seema, “Variables effecting drug entrapment efficiency of microspheres: a review,” International Research Journal of Pharmaceutical and Applied Sciences, vol. 3, no. 3.
[31] J. Fu et al., “High Entrapment Efficiency of Chitosan/Polylactic Acid/Tripolyphotspate Nanosized Microcapsules for Rapamycin by an Emulsion-Evaporation Approach,” Journal of Biomedical Nanotechnology, vol. 6, no. 6, pp. 725–728.
[32] K. S. Shalaby et al., “Determination of factors controlling the particle size and entrapment efficiency of noscapine in PEG/PLA nanoparticles using artificial neural networks,” Int J Nanomedicine, vol. 9, pp. 4953–4964.
[33] J. Jeevanandam, A. Barhoum, Y. S. Chan, A. Dufresne, and M. K. Danquah, “Review on nanoparticles and nanostructured materials: history, sources, toxicity and regulations,” Beilstein J. Nanotechnol., vol. 9, pp. 1050–1074.
[34] N. H. C. Marzuki, R. A. Wahab, and M. A. Hamid, “An overview of nanoemulsion: concepts of development and cosmeceutical applications,” Biotechnology & Biotechnological Equipment, vol. 33, no. 1, pp. 779–797.
[35] W. Rakhmaningtyas, “Preparasi dan karakterisasi nanopartikel sambungsilang kitosan-natrium tripolifosfat dalam sediaan film bukal verapamil hidroklorida,” FMIPA Universitas Indonesia, Jakarta.
[36] A. Nasr, A. Gardouh, H. Ghonaim, E. Abdelghany, and M. Ghorab, “Effect of oils, surfactants and cosurfactants on phase behavior and physicochemical properties of self-nanoemulsifying drug delivery system (SNEDDS) for irbesartan and olmesartan,” International Journal of Applied Pharmaceutics, vol. 8, no. 1, pp. 13–24.
[37] N. Parmar, N. Singla, S. Amin, and K. Kohli, “Study of cosurfactant effect on nanoemulsifying area and development of lercanidipine loaded (SNEDDS) self nanoemulsifying drug delivery system,” Colloids Surf B Biointerfaces, vol. 86, no. 2, pp. 327–338.
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Published
2021-10-31
How to Cite
Hajrin, W., Budastra, W. C. G., Juliantoni, Y., & Subaidah, W. A. (2021). Formulasi dan Karakterisasi Nanopartikel Kitosan Ekstrak Sari Buah Juwet (Syzygium cumini) menggunakan metode Gelasi Ionik: Formulation and characterization of Chitosan Nanoparticle of Juwet (Syzygium cumini) Fruit Extract Using Ionic Gelation Method. Jurnal Sains Dan Kesehatan, 3(5), 742–749. https://doi.org/10.25026/jsk.v3i5.614
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